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PROSITE entry PS00028


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00028
Entry name [info] ZINC_FINGER_C2H2_1
Accession [info] PS00028
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-JUN-1994 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00028

Name and characterization of the entry

Description [info] Zinc finger C2H2 type domain signature.
Pattern [info] 
C-x(2,4)-C-x(3)-[LIVMFYWC]-x(8)-H-x(3,5)-H.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 13'809 in 2'420 different sequences
Number of true positive hits 13'447 in 2'159 different sequences
Number of 'unknown' hits 43 in 14 different sequences
Number of false positive hits 319 in 247 different sequences
Number of false negative sequences 120
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.68 %
Recall (true positives / (true positives + false negatives)) 99.12 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 36
Site [info] zinc at position 1
Site [info] zinc at position 3
Site [info] zinc at position 7
Site [info] zinc at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 2159 sequences 

073L_FRG3G  (Q6GZQ2), A45_SSV1(P20198), ABRU_DROME  (Q24174),
» more

UniProtKB/Swiss-Prot
False negative sequences		 120 sequences 

APTX_CIOIN  (P61802), APTX_DANRE  (P61799), APTX_DROME  (Q8MSG8),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

ESCA_LITFO  (Q02025)


				
	

	

		UniProtKB/Swiss-Prot
'Unknown' sequences		
		
			14 sequences
			


			
ADN2A_DANRE (A4QP16), CIZ1_HUMAN  (Q9ULV3), FSYA_DROME  (P25028), 

			
			» more
			


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			247 sequences
			


			
11014_ASFM2 (P0C9K3), ABC3G_LAGLA (Q694B8), AEGA_ECOLI  (P37127), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			496 PDB
			


			1A1F; 1A1G; 1A1H; 1A1I; 1A1J; 1A1K; 1A1L; 1AAY; 1ARD; 1ARE; 1ARF; 1BBO; 
			
			

			» more